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Influenza-Associated Pediatric Mortality

Case Definition (Updated September 2011)

A pediatric influenza-associated death is defined for surveillance purposes as a death resulting from a clinically compatible illness that was confirmed to be influenza by an appropriate laboratory or rapid diagnositc test in a person aged <18 years. 

A death should not be reported if:  

 
red bullet There is no laboratory confirmation of influenza virus infection.
red bullet The influenza illness is followed by full recovery to baseline health status prior to death.
red bullet The death occurs in a person 18 years or older.
red bullet After review and consultation there is an alternative agreed upon cause of death.
 
Laboratory criteria for diagnosis

Laboratory testing for influenza virus infection may be done on pre- or post-mortem clinical specimens, and include identification of influenza A or B virus infections by a positive result by at least one of the following:

 
red bullet Commercial rapid influenza diagnostic testing of respiratory specimens;
red bullet Influenza virus isolation in tissue cell culture from respiratory specimens;
red bullet Direct or indirect fluorescent antibody staining or respiratory specimens;
red bullet Enzyme immunoassay (EIA) testing of respiratory specimens;
red bullet Reverse-transcriptase polymerase chain reaction (RT-PCR) testing of respiratory specimens;
red bullet Immunohistochemistry (IHC) staining for influenza viral antigens in respiratory tract issue from autopsy specmiens
 
To report a pediatric influenza death, please contact either:

Jill Baber
Influenza Surveillance Coordinator
North Dakota Department of Health
Phone: 800-472-2180 or 701-328-2378
or Michelle Feist
Influenza Program Manager
North Dakota Department of Health
Phone: 800-472-2180 or 701-328-2378